An infusion system can range from something as simple as a needle and syringe to a complex setup that includes catheters, tubing lines, pumps, and all the components in between. The ideal infusion system is one that considers the species being studied, the expertise available in-house, and the ultimate goals of the study. Since infusion studies rarely have a one-size-fits-all solution, we are here to assist you in finding the right approach.

At SAI, our mission is to help you explore your options, ask the right questions, and gain the knowledge needed to design a successful study. We’ll guide you through the available tools, weigh the pros and cons of each option, and share our expertise every step of the way.

To help you get started, here are a few key parameters to consider when planning your infusion study:

While your study species is often predetermined, it’s still essential to design an optimal study plan. Start by considering whether an ambulatory or tethered infusion system is more suitable for your animals and their caging. Also, evaluate the handling process:

• Will using a vascular access port (VAP) make the animal needle-shy?
• Will carrying equipment complicate restraint procedures?
• Are there study parameters that make minimizing handling a priority?

These factors can significantly influence your choice of equipment and overall study design.

A well-planned infusion study must account for the strengths and limitations of your staff. For instance, if your team is accustomed to pin-style catheters, switching to a harness-based system might not be practical without proper training. Even the best equipment is ineffective if the team cannot or will not use it effectively.

That said, some tools, such as implanted buttons and ports in rodents, may have a learning curve but can greatly increase the likelihood of success. Additionally, consider the scheduling demands of large-scale infusion studies. Tasks such as filling, flushing, and locking syringes can be time-consuming, particularly when maintaining pathogen-free conditions. Time-saving solutions like prefilled syringes can reduce staff workload and allow more focus on critical tasks.

The properties of your test compound can influence many aspects of the infusion system, from tubing selection to dosing protocols. While we may not have all the answers, we can help you get started. Consider the following:

• Tubing Compatibility: Use our Reference Table to identify tubing compatibility with common solvents, including their inner diameters (ID) and outer diameters (OD) to calculate system dead volume.
• Syringe Compatibility: Our polycarbonate syringes are compatible with a wide variety of compounds.
• Viscosity: The viscosity of the compound can impact pump accuracy and may cause pressure buildup in the infusion lines. Testing your system beforehand ensures its components, including internal diameters and pump performance, are suitable for the compound.

Important Notes

• Organic solvents may cause deterioration of polymers.
• Compatibility testing is required for all components of the fluid path prior to in-vivo use.

Infusion studies can be complex, but you don’t have to navigate them alone. Contact us with any questions or for guidance in designing your study. We’re committed to helping you achieve success with tailored solutions and expert support.