Insulin sensitivity studies can become complex and challenging, but we are here to provide the support and resources you need for success. Whether your research involves Glucose Tolerance Tests (GTT), Hyperglycemic Clamp techniques, or Hyperinsulinemic-Euglycemic Clamp protocols, we offer expert guidance and tailored recommendations to streamline your process. Explore our curated selection of supplies and solutions below to ensure your studies are conducted with precision, reliability, and ease.

In this study design, a loading dose of glucose (gtt) or insulin (itt) is followed by intermittent blood sampling. The dose is typically administered orally, and since multiple blood samples are needed, an access port is the best tool to make catheter access quick and easy.

In this study design, glucose is infused intravenously with adjustments to reach a steady state. From there, intermittent blood samples are collected and analyzed to establish glucose levels. Since the mouse must be tethered, and low-stress, the CannuLock™ Catheter Access Button™ is an ideal tool.

This protocol relies on intravenous (IV) infusion of insulin to set a baseline, as well as variable rate infusion of glucose (into the same IV line). It’s also common to incorporate an additional channel to dose an experimental compound. Intermittent blood sampling for glucose levels will determine the impact of the drug administration on the mouse.